Selectins & Their Clinical Importance. Selectins are cell surface lectins that have evolved to mediate the adhesion of leukocytes to endothelial cells and platelets under flow. Three selectins have been identified: L-selectin (leukocyte selectin), P-selectin (platelet selectin), and E-selectin (endothelial selectin). In collaboration with other CAM families, selectins play important roles in leukocyte trafficking to the sites of inflammation. | Dr. Najeeb
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Selectins & Their Clinical Importance. Selectins are cell surface lectins that have evolved to mediate the adhesion of leukocytes to endothelial cells and platelets under flow. Three selectins have been identified: L-selectin (leukocyte selectin), P-selectin (platelet selectin), and E-selectin (endothelial selectin). In collaboration with other CAM families, selectins play important roles in leukocyte trafficking to the sites of inflammation. | Dr. Najeeb
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A new theory helps explain blood clots complications in #COVID-19 G. Gregory Neely & team discover the adhesion protein P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells. https://www.jci.org/articles/view/184514 The video shows treatment with anti-P selectin changes localization of labeled SARS-CoV-2 in mouse lung microvasculature. | Journal of Clinical Investigation
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A new theory helps explain blood clots complications in #COVID-19 G. Gregory Neely & team discover the adhesion protein P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells. https://www.jci.org/articles/view/184514 The video shows treatment with anti-P selectin changes localization of labeled SARS-CoV-2 in mouse lung microvasculature. | Journal of Clinical Investigation
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