Cade Otton, TB (vs. SF): Otton posted his first double-digit fantasy point game of the 2025 season last week against Seattle. He could repeat versus a 49ers defense that has allowed 16.3 FPPG to opponents’ tight ends over the past month (ranked 27th).

The Chiefs have already lost to the Chargers, Eagles and Jaguars, and now, they get their toughest test of the season in the Detroit Lions. The Lions will be rolling into Kansas City on a four-game winning streak, which is currently the longest in the NFL.

Week 5 was one of the more unpredictable ones we've seen in the early 2025 NFL season. Fortunately for fantasy managers, it didn't bring another avalanche of significant injuries.

As the Eagles head into Week 6 coming off their first loss of the season, they have moved down in most power rankings. Here’s where they stand.

Week 6 Fantasy Busts: Sit 'Em picks feature Derrick Henry, Trevor Lawrence, Alvin Kamara originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here.

Week 6 will conclude with another Monday Night Football doubleheader. The Buffalo Bills (4-1) will visit the Atlanta Falcons (2-2) and the Chicago Bears (2-2) will visit the Washington Commanders (3-2).

The values assigned to the players below reflect a long-term measurement of their Fantasy value. Values are determined by expected future performance, future schedule, and, most importantly, public sentiment. Past performance isn't a major factor in the Trade Chart.