This is a significant blow to the 49ers' RB room since Taylor had secured a spot as a reliable third or fourth option who contributed on special teams. He posted a career-high 109 yards on 17 carries in San Francisco's Week 18 loss to the Arizona Cardinals last season.

The 49ers wisely have some key veterans, most prominently Nick Bosa, Christian McCaffrey and Trent Williams, on schedules designed to keep them fresh and out of the fray from time to time. Quarterback Brock Purdy is a leader in a more reserved, analytical way. Deommodore Lenoir is stepping up to push the secondary.

Indeed, per Diana Russini of The Athletic, the 49ers are among the teams making calls as they try to acquire another wideout. The Jets are among several teams monitoring the trade market for potential wide receiver additions, per sources. The 49ers and Vikings are also making calls.

The 49ers have committed to Brock Purdy with a big extension. But the key to that deal is the guy standing behind him in the backfield.

Isaac Guerendo and Renardo Green stood out during San Francisco 49ers practice Tuesday as they returned from their respective injuries.

Renardo Green and Isaac Guerendo were among those who returned for a practice in which Brock Purdy and Ricky Pearsall continued to connect.

The injury list for the San Francisco 49ers went through a bit of a shuffle with a few key players returning from injuries Tuesday while significant questions remain on several others just a week before NFL rosters will be cut to 53 players.