Christian McCaffrey (back) has been added to the team's injury report and is listed as questionable for Sunday's game.

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4:25 p.m. ET.

In the past month, they’ve faced three of the top four teams per defensive DVOA and averaged 22.6 points scored in those games. That’s good going when they’ve averaged just 15.5 points across the whole season. The 49ers are averaging 23.6 points per game, and with the Titans showing real signs of improvement, we should see the game total smashed.

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to win the Week 15 NFL game.

There are four teams on a bye in Week 14, the final bye week of the season. The 49ers, Giants, Panthers and Patriots are on a bye this week. More: NFL Week 14 picks straight up and against spread: Packers or Bears in NFC North showdown?

Sunday’s game at Levi’s Stadium could get out of hand quickly. The San Francisco 49ers will host the Tennessee Titans as 12.5-point favorites in Week 15. The un

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.

Field Yates' 2026 NFL mock draft has the 49ers adding DT Caleb Banks as San Francisco continues its defensive line revamp for a stronger 2026 season.