Certain mutations in the GBA1 gene are the most common genetic risk factors for Parkinson’s disease; even so, most people with these variants never develop PD. Now, scientists led by Anthony Schapira ...

CAR-T cell therapy has practically become a household name, given its success in taking down blood cancers. The chimeric antigen receptors used in this type of cell therapy are designed to sic killer ...

Interconnected networks of neurons—i.e., circuits—are the basis of brain function, and astrocytes support synapses within them. They also form networks of their own, passing messages and sharing ...

Scientists are trying to parse the cellular interactions that foment ARIA during amyloid immunotherapy. At last month’s AD/PD conference in Copenhagen, Denmark, speakers highlighted the role of both ...

Mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Curiously, variants in another gene, TMEM106B, determine when, and how severely, this ...

Professional Information CEO, AUTOTAC Bio Inc., Seoul KoreaProfessor, Seoul National University College of Medicine Inside Job: Antibody Flags Toxic Tau for Disposal by Lysosome 24 Apr 2026 ...

Tau immunotherapy has been hindered by poor antibody access across the blood-brain barrier and weak binding to target epitopes. The trial failures of many full-length antibodies against various ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

This database provides information about selected rodent models of neurodegenerative disease, including Alzheimer’s, Parkinson’s, and ALS. By summarizing, visualizing, and continuously updating ...

In 2009, Robert Baloh and colleagues reported a transgenic mouse model of ALS based on the overexpression of mutant TARDBP (TDP-43) (Wegorzewska et al., 2009). These mice developed several features of ...

These transgenic mice overexpress mutant human LRRK2 throughout the brain via a promoter that drives neuronal-specific expression (Ramonet et al., 2011). Nonetheless, the mutant human protein is also ...

Parkin Flx/Flx mice allow for conditional knockout of the Prkn gene using a Cre-loxP recombination system (Shin et al., 2011). This approach aims to overcome the developmental compensation seen in ...