A new research paper was published in Volume 16 of Genes & Cancer on January 20, 2025, entitled, "Analysis of pathogenic variants in retinoblastoma reveals a potential gain of function mutation." ...

Dominant-Negative Effect Mechanisms Worsen the Effects of Loss-of-Function Mutations Several factors make p53 more vulnerable to inactivation compared to other tumor suppressors.

“ But it will require that we take a fresh look at the regulatory requirements and find innovative ways to address the needs of patients with heterozygous toxic gain-of-function mutations.” ...