Best of luck with your picks! As a heads up, there are two Saturday games this weekend, so don’t wait until Sunday morning to get your picks in.

Should I start Colby Parkinson, Jordan Whittington, Blake Corum for Week 16? Fantasy football start 'em, sit 'em picks and recommendations for the 2025 NFL season.

Now, he's going up against a Jets defense that just allowed Trevor Lawrence to post six total touchdowns (five passing and one rushing), which led to the firing of defensive coordinator Steve Wilks. Shough shouldn't face much resistance this week, which could make it very hard for undrafted rookie Brady Cook to keep up in his second career start.

The problems last week were that Ole Miss’s Lane Kiffin circus did not keep them from beating the hell out of Mississippi State while Texas upset Texas A&M. Michigan and Georgia Tech keeping it close with Ohio State and Georgia,

Matt's running back (RB) fantasy football start 'em, sit 'em picks for Week 16 of 2025. His RB lineups advice for Week 16 fantasy football start/sit decisions.