A collaboration of Japanese scientists are gaining important new insight into the function of the tob gene, and shedding new light on its role in human cancer. Their report is published in the May ...

The quiescent state of unstimulated T lymphocytes is thought to be due to a lack of activation signals. Efficient ligation of the T cell receptor (TCR) by high-density antigen can generate a ...

In higher eukaryotes, cell proliferation is regulated by extra- and intracellular signals. These signals lead to activation of cyclin-dependent protein kinases (CDKs), which are important for cell ...