Setting out to identify all proteins that make up the sarcomere, the basic contractile unit of muscle cells, resulted in an unexpected revelation, providing experimental evidence that helps explain a ...

Alpha-actinin can cross-link actin filaments and anchor them to the Z-disk in sarcomeres. Sarcomeres are a structural unit of myofibril in striated muscle. The FATZ (filamin, α-actinin- and telethonin ...

Researchers at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) developed a mouse model that enables them to look inside a working muscle and identify the proteins ...

Adding to the growing fundamental understanding of the machinery of muscle cells, a group of biophysicists describe -- in minute detail -- how actin filaments are stabilized at one of their ends to ...

Scientists at the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association say they have developed a mouse model that enables them to look inside a working muscle and identify the ...

New research links abnormal cholesterol signalling with cardiomyocyte dysfunction in DCM, uncovering a potential treatment target. Read more.