Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 ...

San Francisco Pro Bowl tight end George Kittle misses practice with an ankle injury, leaving his status for Sunday's game ...

In the final game of what has been a wild Week 16, the Indianapolis Colts host the San Francisco 49ers on "Monday Night ...

This week’s Monday Night Football features the San Francisco 49ers visiting the Indianapolis Colts. The 49ers are 10-4, but ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

Where do the 49ers rank in Week 17 power rankings after their blowout win over the Colts? See how national media views San Francisco's surge.

The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never ...

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the ...

The San Francisco 49ers and Indianapolis Colts meet for Monday Night Football at Lucas Oil Stadium in Indianapolis, Indiana. Kickoff is at 8:15 ET.

San Francisco 49ers quarterback Brock Purdy is sparing no expense to help his community during the holiday season. It's a tradition around this time of the year for NFL quarterbacks to give their ...

Chicago Bears head to San Francisco to take on the 49ers, aiming for the top spot. Don't miss this thrilling game!

The San Francisco 49ers and Indianapolis Colts meet for Monday Night Football with an 8:15 p.m. ET kickoff at Lucas Oil Stadium. Here are the best prop bets for the game.