Panelists explain that KMT2A-rearranged acute myeloid leukemia (AML) is an aggressive, molecularly distinct leukemia subtype marked by menin-dependent transcriptional dysregulation, poor response to ...

He works in mysterious ways.

Here we have focused on the function of TGIF1 in MLL-rearranged AML and demonstrate that it interferes with an MEIS1-dependent transcriptional network required for AML maintenance by directly ...

Cancerous cells arise when somatic cells are able to escape the restraints that normally withhold them from unlimited expansion. Cancer progression is thought to be the net result of signaling through ...