During the pathogenesis of Parkinson’s disease (PD), α-synuclein pathology may originate in peripheral organs and spread to the CNS. Using human tissue samples and multiple approaches in mouse ...

In addition to its widely recognized effects on gait, posture, balance, and upper limb coordination, Parkinson ... disease history of more than 10 years. This article discusses the pathophysiology ...

Parkinson's disease (PD) is a common neurodegenerative disorder, affecting about one percent of the population over the age of 60 years. While the typical age at onset is in the sixth decade of life ...