Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in various cholestatic disorders. Several potential mechanisms and sites of action of UDCA have been unraveled in clinical and experimental ...

A search for rebound gastric hypersecretion after ingestion of antacids in patients with duodenal ulcer revealed that aluminum-magnesium hydroxide (in a dose of 30 or 60 ml) and sodium bicarbonate (in ...

Inappropriate levels of gastric acid underlie several widespread pathological conditions, including gastroesophageal reflux disease (GERD) and peptic ulcers. Control of the complex mechanism of ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Acid peptic disorders are the result of distinctive, but overlapping pathogenic mechanisms leading to either excessive acid secretion or diminished mucosal defense. They are common entities present in ...

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years. Now Niederweis ...

In a study that could revolutionize how millions of people are treated for painful gastric acid-related diseases, a team led by Yale School of Medicine researchers has shown that zinc salts offer ...