Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity.

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 100 million infections and millions of deaths. Effective vaccines remain the best hope of ...

MHC-I presents viral antigens for CD8+ cytotoxic T lymphocyte (CTL) activation. Upon activation, these cells kill and eliminate virus-infected cells throughout the human body. Several viruses have ...

The chicken major histocompatibility complex (MHC) represents a compact and evolutionarily distinct genomic region that plays a critical role in orchestrating adaptive immunity. Characterised by a ...

When early Stone Age farmers first moved into Europe from the Near East about 8,000 years ago, they met and began mixing with the existing hunter-gatherer populations. Now genome-wide studies of ...

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.

Peptides that bind major histocompatibility complex (MHC) class I molecules act as chemosensory signals in a region of the brain thought to be important in chemosensory communication, according to a ...

The adaptive immune system is an antigen-specific structure that discriminates non-self molecules through the recognition of peptide antigens using receptor interactions between T-cells and ...