Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

A new microscope method reveals details that were difficult to see before, helping researchers study proteins, cells, and ...

During image analysis, researchers use light sheet microscopy of cleared tissue as a preferred method for high throughput volumetric imaging. A flexible system can provide a range of sizes, resolution ...

In biology, seeing can lead to understanding, and researchers in Professor Edward Boyden's lab at the McGovern Institute for Brain Research are committed to bringing life into sharper focus. With a ...

It is the computational processing of images that reveals the finest details of a sample placed under all kinds of different light microscopes. Even though this processing has come a long way, there ...

Our brain is a complex organ. Billions of nerve cells are wired in an intricate network, constantly processing signals, enabling us to recall memories or to move our bodies. Making sense of this ...

Confocal microscopy is a specialized fluorescence imaging technique that scientists use to acquire images at greater resolution than conventional microscopy. 1 In addition to scanning the lateral x ...

Recently developed descanned versions of the oblique light-sheet microscope promise to enable high-frame rate volumetric imaging in a variety of convenient preparations. The efficiency of these ...

In 1931, physicists Knoll and Ruska unveiled the first electron microscope, revolutionizing science by using magnetic lenses ...

Berkeley Lab and UC Berkeley physicists' new technique offers detailed images of the small molecules and cell structures that ...