One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are segments of noncoding DNA that must be removed from the genetic code ...

In the genome, genes that code for protein are often divided into sections called exons, which are separated by spacers called introns. When a region of DNA is transcribed into messenger RNA (mRNA) or ...

This process enables a single gene to produce multiple proteins; over evolutionary timescales, splicing can also change the size and content of genes and proteins, when different exons become included ...

Human introns have extensively varying lengths. Previously, only U2AF-dependent splicing was known. Researchers from Fujita Health University now show that splicing in a subset of human short introns ...

Researchers at the University of Toronto's Donnelly Center for Cellular and Biomolecular Research have found nearly one million new exons—stretches of DNA that are expressed in mature RNA—in the human ...

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing production of certain messenger RNAs and appear to help cells respond to ...

Effect of IKKϵ knock-down on prostate cancer xenograft growth. Background: Activating EGFR mutations have become a backbone in the therapy alogrithm for NSCLC as mutations predict significantly better ...

A new study points to introners, one of several proposed mechanisms for the creation of introns, as an explanation for the origins of most introns across species. One of the most long-standing, ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor, new research finds. The interrupted non-coding regions in pre-mRNAs, termed ...

The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins. As human pre-mRNA introns vary in length ...