Cholesterol biosynthesis disorders encompass a group of inborn errors and pharmacologically induced perturbations affecting the multistep metabolic cascade that generates cholesterol from acetyl-CoA.

Since then, many scientists, including Lu, who now leads his own research group at Western University, have shown that PIN1 is overexpressed in different types of cancer and regulates many oncogenes ...

New research links abnormal cholesterol signalling with cardiomyocyte dysfunction in DCM, uncovering a potential treatment target. Read more.

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce ...

A research team from the LKS Faculty of Medicine at the University of Hong Kong (HKUMed) has made a breakthrough in gastric cancer research, revealing how the "second brain"—nerves in the digestive ...

Sterols, such as cholesterol in our bodies or ergosterol in yeast cells, are among the most abundant lipids in eukaryotic cells, yet are synthesized through notoriously long, complex metabolic ...

Researchers discover novel targets for bladder cancer therapeutics and demonstrate that a new combination of existing drugs, including statins, blocks tumor growth in mice. Like all cancers, bladder ...

This depletion process ultimately relies on an enzyme called cathepsin A (CTSA). The researchers found that blocking CTSA ...