For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular ...

Immunotherapies – treatments that aim to make the body's natural immune system more effective – are becoming more widely used ...

Since 2022, mpox virus (MPXV), a zoonotic orthopoxvirus closely related to variola virus (VARV), has triggered a global outbreak of unprecedented scale and geographic reach. Initial clusters in ...

A researcher at the Hackensack Meridian Center for Discovery and Innovation (CDI) and physician-scientist colleagues from Hackensack Meridian Health have shown how a critical pathway is fundamental to ...

Researchers from National Taiwan University (NTU) and National Taiwan University Hospital (NTUH) have identified a promising ...

Widespread yellow fever virus (YFV) immunity in Sub-Saharan Africa may mitigate orthoflavivirus outbreaks. Here, we investigate whether pre-existing YFV-17D immunity confers cross-protection against ...

The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the execution of defense and clearance functions. Immunosenescence not only ...

Scientists have uncovered new genetic rules that determine whether the immune system’s “killer” T cells remain powerful long-term defenders or become worn out and ineffective. By building a detailed ...

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. The study demonstrated that inducing cancer cells to ...

Cancer-fighting T cells do not simply “run out of energy.” They are molecularly reprogrammed. For years, mitochondrial dysfunction has been recognized as a hallmark of exhausted T cells in tumors. Yet ...