Researchers have developed a novel method for simultaneously recording action potentials (APs)—temporary changes in electrical potential when cells become excited—and calcium transients—calcium ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Calcium-activated ion channels in smooth muscle cells translate intracellular calcium signals into changes in membrane potential and contractile tension. The most prominent of these channels are the ...

A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness. Researchers found that certain statins can latch onto a key muscle protein and ...

Cells have to invest a lot of energy to maintain this concentration gradient, especially when it comes to getting rid of calcium. 'It's like being on a rush-hour train in a city like Tokyo. When the ...

Penile erection is a complex and regulated process that involves the dilation of penile blood vessels, the relaxation of smooth muscle, increased intracavernosal blood flow, and veno-occlusive ...