The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

See the Titans vs 49ers game stats from the 37-24 loss on Dec. 14, 2025, including match player stats and team stats.

Tennessee lost 37-24 to the San Francisco 49ers on Dec. 14 at Levi's Stadium, with the 49ers scoring on their first five drives and seven of eight possessions overall. Brock Purdy threw for 295 yards and three touchdowns, while Murfreesboro's Jauan Jennings caught two touchdown passes.

The San Francisco 49ers are back in prime time tonight, hosting the Carolina Panthers at Levi's Stadium. Fresh off a 41-22 win over the Arizona Cardinals, the Niners looked sharp in quarterback Brock Purdy's return from a turf toe injury. Purdy threw for ...

Maurice Moton of Bleacher Report isn’t sold on the excellent offensive stretch from the 49ers, citing the opponents.

In the 49ers’ last matchup against the Tennessee Titans, Pearsall injured his ankle on the very first play from scrimmage but returned to the game. He battled through the injury all game before suffering another knee setback to add to his woes.