San Francisco 49ers wide receiver Ricky Pearsall will miss Monday night's game against the Indianapolis Colts after ...

Ricky Pearsall played a key role in the San Francisco 49ers ' Week 15 win over the Tennessee Titans on Sunday. The ...

SANTA CLARA, Calif. (AP) — Brock Purdy threw three touchdown passes and the San Francisco 49ers started the stretch run of ...

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to ...

The San Francisco 49ers got what they needed with the Seattle Seahawks win in Week 16, but one of their players learned a key lesson on a wacky play.

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Mike Florio is picking the 49ers to win by a touchdown, while Chris Simms is taking San Francisco by 15. "The Colts have found a way to complete their collapse in style," Florio wrote. A clean sweep - ...

Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.

Jason Logan breaks down his early 49ers vs. Colts predictions and explains why there's value backing the home underdog. Free ...

San Francisco 49ers superstar running back Christian McCaffrey has a shot to making franchise history with a team legend in his crosshairs.